Sale fanned Jhonny Peralta in the sixth inning for his 10th strikeout.
He also averaged more than a strikeout per inning this year, fanning 59 hitters.
725295 The Goderich, Ont., native promptly got an emphatic strikeout to end the game.
Kyle Gibson faces Carlos Carrasco, coming off a 15-strikeout on-hitter, in the opener.
It was his third double-digit strikeout effort of the season and the 23rd of his career.
By the end of his six innings, the Rays would fall victim to Nola six times by strikeout.
He reached 300 on a swinging strikeout of Upton to end the third, earning a standing ovation.